Oral Semaglutide Metabolic Outcomes Study

Join a 6-month observational research study on oral semaglutide (Wegovy®) for adults currently prescribed through Hims & Hers
See if you qualify

Join a 6-month remote study exploring how oral semaglutide (Wegovy®) affects metabolic and inflammatory health markers in adults prescribed the medication through the Hims & Hers telehealth platform. Your participation helps build real-world evidence on how this treatment works in everyday life — entirely from your home. Participation is limited to patients who are currently prescribed oral semaglutide through the Hims & Hers platform.

About This Study

At-Home Remote Study
No clinic visits required. Everything is completed remotely through the Alethios app from your phone or computer.
Baseline Assessments
You will complete baseline assessments and regular surveys through the course of the study.
Compensation Available
Participants who meet study requirements will receive up to $150 in Amazon gift cards — $50 at baseline, $50 at Month 3, and $50 at Month 6.
Observational Study
This single-group, pre-post observational study explores real-world changes in metabolic and inflammatory health markers among adults prescribed oral semaglutide through a telehealth platform.

What's Involved

Participation is fully remote and takes place through the Alethios app. You’ll complete short surveys about your weight, energy, appetite, and how you’re feeling at three timepoints over 6 months. Monthly check-ins keep things on track and give you a chance to report anything important.

Check Eligibility and Enroll

Complete a short screening questionnaire to confirm you qualify. If eligible, review the study details and sign your electronic consent form through the Alethios platform.

Complete Onboarding and Baseline Assessments

Complete your baseline demographics, medical history, and initial questionnaires through the Alethios app. Confirm receipt of your GLP-1 on the platform as soon as you receive it.

Complete Monthly Check-Ins and Mid-Study Assessments.

Each month, complete brief check-ins about your weight, energy, appetite, and medication adherence.

Complete Final Assessment and Receive Compensation

At Month 6, complete your final surveys and at-home blood collection. Adherent participants will receive up to $150 in Amazon gift cards — $50 at baseline, $50 at Month 3, and $50 at Month 6.

What's Being Studied?

This study is examining how oral semaglutide (Wegovy®) — a pill prescribed for weight management — affects key metabolic and inflammatory markers in real-world patients. While clinical trials have shown that semaglutide helps with weight loss, less is known about how it affects things like blood sugar, cholesterol, inflammation, and liver function when prescribed through a telehealth platform. This study tracks those changes over 6 months using at-home blood testing and regular check-in surveys.

Am I eligible?

You may be eligible if you meet the following requirements

See if you qualify
Currently prescribed oral semaglutide (Wegovy®) through Hims & Hers (this will be verified)
Adults 18 years or older
BMI of 23 or higher
Not currently enrolled in another clinical trial
No established Type 1 or Type 2 diabetes diagnosis
Not pregnant or breastfeeding
Not prescribed semaglutide solely for study participation