TEND: Trial Evaluating Nutritional fiber in Digestive symptoms of endometriosis

Join a 12-week remote study on fiber, the gut and vaginal microbiome, and digestive symptoms in women with endometriosis.
See if you qualify

An at-home study for women with endometriosis and ongoing digestive symptoms. Take a supplement or matched placebo twice daily, complete a 2-minute daily check-in, collect samples at home three times, and answer questionnaires at four timepoints.

About This Study

Up to $150 in Compensation
Earn up to $90 as an Amazon gift card across five stages, plus a one-time $60 LOAM storefront credit at the end.
At-Home Sample Collection
Self-collect a stool sample and a vaginal swab in private at home, three times during the study, each mailed back in a prepaid USPS envelope.
Your Own Microbiome Results
After the study closes, receive an encrypted report on your own gut and vaginal microbiome samples.
Fully Remote Study
Complete every part of this study from home through the Alethios app. No clinic visits are required.

What's Involved

For 12 weeks, take one scoop of your study supplement or matched placebo each morning and evening. You'll complete a 2-minute daily check-in, questionnaires at four timepoints, a three-day food record three times, and collect a stool sample and vaginal swab at home on your first study day, Week 6, and Week 12, each mailed back in a prepaid envelope. Everything is done through the Alethios app, no clinic visits required.

Complete Screening and Onboarding

Complete a short eligibility questionnaire, provide evidence of your endometriosis, and complete a brief video or phone call with the study team, then finish your onboarding activities and sign your consent electronically before your kit ships.

Start Your Supplement and Baseline Collection

Once your Study Supplement and Sample Collection Kit arrive, take your first two doses, record your baseline weight and waist measurement, and collect your first stool sample and vaginal swab.

Take Your Daily Doses and Complete Check-Ins

Take one dose in the morning and one in the evening for 12 weeks, complete a 2-minute daily check-in, and complete questionnaires and a second sample collection at Week 6.

Complete Final Assessments and Receive Compensation

At Week 12, complete your final questionnaires and sample collection, then receive your final compensation stage.

What's Being Studied?

This study looks at how a multi-fiber prebiotic supplement relates to the bacteria living in your gut and vagina, your digestive symptoms, and your day-to-day well-being in women with endometriosis. Researchers track this using at-home stool and vaginal swab samples, daily and periodic questionnaires, and body measurements over 12 weeks, comparing the fiber supplement to a matched placebo.

Am I eligible?

You may be eligible if you meet the following requirements

See if you qualify
Confirmed diagnosis of endometriosis by imaging, laparoscopy, or physician clinical assessment
Digestive symptoms, such as bloating, constipation, or abdominal discomfort, on 3 or more days a week for the past 3 months
Assigned female at birth, 18 to 45 years old
No hormonal therapy, or hormonal therapy unchanged for at least 3 months, with no planned change during the study
Habitual dietary fiber intake below 25 g per day
Willing to keep diet, physical activity, and medication routines stable throughout the study
Willing to complete at-home stool and vaginal swab self-collection three times during the study
Not pregnant, breastfeeding, or planning to become pregnant during the study
No inflammatory bowel disease, celiac disease, or other diagnosed gastrointestinal disease
Does not live in New York, Rhode Island, or Puerto Rico